Nalmefene is an opioid antagonist with a chemical structure similar to naltrexone.
(Naltrexone has been most recently used in the procedure known as "rapid detox" for narcotic addicts.) Scientific studies have shown that nalmefene is effective in preventing alcoholics from relapsing to drinking when compared to a placebo. A study showed that the nalmefene does not produce morphine-like effects and has low potential for abuse.
Clinical trials have shown Nalmefene is effective for the prevention of relapse in alcohol-dependent patients. Scientists have suggested that it should be considered a first-line therapy when it becomes available in the United States. Alcoholics who took nalmefene showed prompt response, but more than one third of participants receiving nalmefene relapsed, despite weekly follow-up visits and cognitive behavioral therapy.
The full chemical name is 17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-diol.
Impulse control disorders (ICDs), include pathological gambling, trichotillomania (excessive self-grooming such as pulling out hair), and kleptomania. Also pathological gamblers, compulsive buyers, and binge eating. At one time these were thought of as being somewhere an impulsive–compulsive spectrum. Recent data have suggested that these disorders may be considered addictions. The treatment of ICD with serotonergic drugs is, therefore, empirically oriented.
Nalmefene is an opioid receptor agonist.
Used for alcoholism
What an opioid receptor agonist?